Tetrahedron has developed new synthetic processes allowing the industrial production of the following known compounds:
Tetrahedron has also designed new and proprietary antioxidants, which are selenoorganic compounds:
  • The basic structure is NutraSelen® (THD-177) which is a novel organic source of selenium, in particular through its ability to be bioconverted into L-selenomethionine, the natural source of selenium in human and animals.

A licensing agreement was signed to use NutraSelen® in Animal Nutrition.

Tetrahedron is a supplier of NutraSelen® (see below) as well as of L-(+)-ergothioneine, S-methyl-L-ergothioneine and L-2-thiohistidine, which can be ordered on line (see below) according to our General Conditions of Sale ("Conditions générales de vente "). For request of quotation on larger quantities, please contact us.

Product CAS RN
Molecular formula
Molecular weight (g/mol)
Purity* To order**
(*) by 1H-NMR (**) DDU    
NutraSelen® 873660-49-2
C5H10O3Se
197.1		 ≥98% on request
L-Ergothioneine 497-30-3
C9H15N3O2S
229.3		 ≥98%
Package
semi-bulk on request
S-Methyl-L-ergothioneine -
C10H17N3O2S
243.3		 ≥98%
Package
L-2-Thiohistidine 2002-22-4
C6H9N3O2S
187.2		 ≥97%
Package
semi-bulk on request


For academics, free 100-mg samples of L-2-thiohistidine and NutraSelen® are available upon request.

Tetrahedron is also a supplier of the following series of compounds, which can be ordered on line (see below) according to our General Conditions of Sale ("Conditions générales de vente"):

A/ 2-Thioimidazoles compounds

Product CAS RN
Molecular formula
Molecular weight (g/mol)		 Purity* To order**
(*) by 1H-NMR (**) DDU
D-Ergothioneine -
C9H15N3O2S
229.3		 ≥98%
Package
D-2-Thiohistidine -
C6H9N3O2S
187.2		 ≥97%
Package
D,L-2-Thiohistidine 13552-61-9
C6H9N3O2S
187.2		 ≥97%
Package
α-N-Methyl-
L-2-thiohistidine		 -
C7H11N3O2S
201.2		 ≥98%
Package
α-N,N-Dimethyl-
L-2-thiohistidine		 170227-63-1
C8H13N3O2S
215.2		 ≥98%
Package

B/ Protected derivatives of 2-thiohistidine

With regard to the interesting properties of L-2-thiohistidine, its following series of derivatives have been designed to introduce it into peptides or polymers and thus provide the opportunity of investigating the properties of new and patentable compounds.

Series of S- or N-protected derivatives of 2-thiohistidine:

In this series, the following monoprotected compounds correspond to the general formula

      • where P1=H and P2=Boc
      • or P1=tBu, Mob or DNP and P2=H


Product*
(ref)

CAS RN
Molecular formula
Molecular weight (g/mol)		 Purity** To order***
(*) designation based on the adoption of "H-2-Thiohis-OH" for 2-thiohistidine
(**) by 1H-NMR
(***) DDU
Boc-2-Thiohis-OH
(THD-268)		 -
C11H17N3O4S
287.3		 ≥95%
Package
H-2-Thiohis(tBu)-OH
(THD-269)		 -
C10H17N3O2S
243.3		 ≥95%
Package
H-2-Thiohis(Mob)-OH
(THD-270)		 -
C14H17N3O3S
307.4		 ≥95%
Package
H-2-Thiohis(DNP)-OH
(THD-271)		 -
C12H11N5O6S
353.3		 ≥95%
Package
Set of the 4 monoprotected compounds
Package


Series of S- and N-protected derivatives of 2-thiohistidine:

In this series, the following diprotected compounds correspond to the general formula

      • where P1=tBu, Mob or DNP and P2=Boc, Fmoc, Z or Trt


Product*
(ref)

CAS RN
Molecular formula
Molecular weight (g/mol)		 Purity** To order***
(*) designation based on the adoption of "H-2-Thiohis-OH" for 2-thiohistidine
(**) by 1H-NMR
(***) DDU
Boc-2-Thiohis(tBu)-OH
(THD-272)		 -
C15H25N3O4S
343.4		 ≥95%
Package
Fmoc-2-Thiohis(tBu)-OH
(THD-273)		 -
C25H27N3O4S
465.6		 ≥95%
Package
Z-2-Thiohis(tBu)-OH
(THD-274)		 -
C18H23N3O4S
377.5		 ≥95%
Package
Trt-2-Thiohis(tBu)-OH
(THD-275)		 -
C29H31N3O2S
485.6		 ≥95%
Package
Boc-2-Thiohis(Mob)-OH
(THD-276)		 -
C19H25N3O5S
407.5		 ≥95%
Package
Fmoc-2-Thiohis(Mob)-OH
(THD-277)		 -
C29H27N3O5S
529.6		 ≥95%
Package
Z-2-Thiohis(Mob)-OH
(THD-278)		 -
C22H23N3O5S
441.5		 ≥95%
Package
Trt-2-Thiohis(Mob)-OH
(THD-279)		 -
C33H31N3O3S
549.7		 ≥95%
Package
Boc-2-Thiohis(DNP)-OH
(THD-280)		 -
C17H19N5O8S
453.4		 ≥95%
Package
Fmoc-2-Thiohis(DNP)-OH
(THD-281)		 -
C27H21N5O8S
575.6		 ≥95%
Package
Z-2-Thiohis(DNP)-OH
(THD-282)		 -
C20H17N5O8S
487.4		 ≥95%
Package
Trt-2-Thiohis(DNP)-OH
(THD-283)		 -
C31H25N5O6S
595.6		 ≥95%
Package
Set of the 12 S- and N-protected compounds
Package


Series of S- and O-protected derivatives of 2-thiohistidine:

In this series, the following diprotected compounds correspond to the general formula

      • where P1=tBu, Mob or DNP and P3=Me, Bn or All


Product*
(ref)

CAS RN
Molecular formula
Molecular weight (g/mol)		 Purity** To order***
(*) designation based on the adoption of "H-2-Thiohis-OH" for 2-thiohistidine
(**) by 1H-NMR
(***) DDU
H-2-Thiohis(tBu)-OMe.2HCl
(THD-284)		 -
C11H19N3O2S,2HCl
330.3		 ≥95%
Package
H-2-Thiohis(tBu)-OBn.2HCl
(THD-285)		 -
C11H23N3O2S,2HCl
406.4		 ≥95%
Package
H-2-Thiohis(tBu)-OAll.2HCl
(THD-286)		 -
C13H21N3O2S,2HCl
356.3		 ≥95%
Package
H-2-Thiohis(Mob)-OMe.2HCl
(THD-287)		 -
C15H19N3O3S,2HCl
394.3		 ≥95%
Package
H-2-Thiohis(Mob)-OBn.2HCl
(THD-288)		 -
C21H23N3O3S,2HCl
470.4		 ≥95%
Package
H-2-Thiohis(Mob)-OAll.2HCl.H2O
(THD-289)		 -
C17H21N3O3S,2HCl,H2O
438.4		 ≥95%
Package
H-2-Thiohis(DNP)-OMe.2HCl.H2O
(THD-290)		 -
C13H13N5O6S,2HCl,H2O
458.3		 ≥95%
Package
H-2-Thiohis(DNP)-OBn.2HCl
(THD-291)		 -
C19H17N5O6S,2HCl
516.4		 ≥95%
Package
H-2-Thiohis(DNP)-OAll.2HCl
(THD-292)		 -
C15H17N5O7S,2HCl
466.3		 ≥95%
Package
Set of the 9 S- and O-protected compounds
Package
Set of the 25 protected compounds
Package